Penstrep-400

Penstrep-400 — Injectable Antibacterial Suspension

Penstrep-400 is a sterile injectable veterinary suspension combining procaine penicillin G 200,000 IU/mL and dihydrostreptomycin sulfate 200 mg/mL. It is indicated for certain bacterial infections in cattle, calves, sheep, goats, and swine, and must be used only under veterinary direction.medicines.health.europa+1

Product Overview

Penstrep-400 is a combination antibacterial injection formulated to deliver two complementary active ingredients in one suspension. Each milliliter contains procaine penicillin G at 200,000 IU and dihydrostreptomycin sulfate at 200 mg.interchemie+1

Procaine penicillin G is a beta-lactam antibacterial that is principally active against susceptible Gram-positive organisms. Dihydrostreptomycin sulfate is an aminoglycoside with activity principally against susceptible Gram-negative organisms. Used together, the two components may have additive activity and, in some cases, synergistic activity against susceptible bacteria.interchemie+1

Intended Veterinary Use

Penstrep-400 is labeled for the treatment of susceptible bacterial infections in cattle, calves, sheep, goats, and swine. Manufacturer information lists conditions including arthritis, mastitis, and gastrointestinal, respiratory, and urinary tract infections caused by organisms sensitive to penicillin and dihydrostreptomycin.interchemie+1

Susceptible organisms identified in the product information include Campylobacter, Clostridium, Corynebacterium, Escherichia coli, Erysipelothrix, Haemophilus, Klebsiella, Listeria, Pasteurella, Salmonella, Staphylococcus, and Streptococcus species. Effective treatment depends on correct diagnosis, appropriate antimicrobial selection, and confirmation that the infection is caused by a susceptible organism.interchemie

Important Equine Safety Notice

Although some penicillin-streptomycin combination products have historically been used in horses in certain countries, the Penstrep-400 label cited here specifies cattle, calves, sheep, goats, and swine—not horses. Do not use Penstrep-400 in horses except when a licensed veterinarian specifically determines that off-label use is appropriate, lawful, and necessary for that individual animal.medicines.health.europa+2

Horses requiring antibacterial treatment should receive a veterinary examination and, where appropriate, culture and sensitivity testing. A veterinarian can select an approved equine treatment, calculate the correct dose, choose a safe injection site, and monitor for adverse reactions.

Administration and Professional Guidance

Penstrep-400 is administered by intramuscular injection. The manufacturer’s labeled cattle dosage is 1 mL per 20 kg body weight once daily for three days, while calves, sheep, goats, and swine have a labeled dosage of 1 mL per 10 kg body weight once daily for three days.interchemie+1

Before use, shake the vial thoroughly to ensure a uniform suspension. Do not exceed the maximum injection-site volumes stated on the product labeling, and avoid repeated injections into the same site.batnanpharma+1

Because this is a prescription antibiotic, dosing, duration, withdrawal periods, and injection technique should be established by a veterinarian. Incorrect antibiotic use can contribute to treatment failure, adverse reactions, tissue damage, residue violations, and antimicrobial resistance.

Safety, Warnings, and Withdrawal

Do not use Penstrep-400 in animals with known hypersensitivity to penicillins, procaine, or aminoglycosides. The product information also identifies severe renal impairment and concurrent administration with certain antimicrobial classes, including tetracyclines, chloramphenicol, macrolides, and lincosamides, as contraindications or cautions.batnanpharma

Potential adverse effects associated with aminoglycosides can include ototoxicity, neurotoxicity, and nephrotoxicity, particularly with excessive exposure or impaired kidney function. Hypersensitivity reactions can also occur.batnanpharma+1

Observe all meat and milk withdrawal periods specified on the product labeling and required by local regulations. One product listing states withdrawal periods of 21 days for meat, 3 days for milk, and 45 days for kidneys; always follow the withdrawal period applicable to the specific authorized product and jurisdiction.batnanpharma

Storage and Handling

Store Penstrep-400 according to the manufacturer’s label, protected from light and extreme temperatures. Keep the vial tightly closed, shake well before each use, and discard any product that shows unusual discoloration, contamination, or a broken seal.

Keep out of reach of children, unauthorized personnel, and animals. Handle sharps safely and dispose of used needles and vials in accordance with local veterinary and environmental regulations.

Why Order from Equine Pharma World

Equine Pharma World provides clearly described veterinary products, secure checkout, and rapid, discreet worldwide delivery. Penstrep-400 is intended for professional veterinary use in its labeled livestock species, and customers should ensure compliance with local prescription, import, and antimicrobial-use regulations before ordering.medicines.health.europa+1

Penstrep-400 — a dual-action injectable antibacterial suspension combining procaine penicillin G and dihydrostreptomycin sulfate for susceptible infections in labeled livestock, supplied for responsible veterinary use.